Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046506 | 0.90 | EGFR (0.53) | EGFRTNK2METPRMT5KDR | |
| SCHEMBL4047011 | 0.88 | EGFR (0.56) | EGFRTNK2METKDRFGFR1 | |
| SCHEMBL3950078 | 0.85 | EGFR (0.72) | EGFRTNK2KDRFGFR1FGFR2 | |
| SCHEMBL4045565 | 0.80 | EGFR (0.58) | EGFRTNK2METKDRFGFR1 | |
| SCHEMBL4047217 | 0.77 | EGFR (0.73) | EGFRFGFR1FGFR2FGFR3 | |
| SCHEMBL2387612 | 0.77 | MET (0.62) | EGFRTNK2METKDRFGFR1 | |
| SCHEMBL24288969 | 0.76 | FGFR1 (0.63) | TNK2METKDRFGFR1FGFR2 | |
| SCHEMBL4048129 | 0.75 | EGFR (0.64) | EGFRTNK2FGFR1FGFR2FGFR3 | |
| SCHEMBL4043236 | 0.75 | EGFR (0.79) | EGFRMETKDRATRPIK3CD | |
| SCHEMBL29521878 | 0.74 | TNK2 (0.53) | EGFRTNK2METKDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |