Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.32 |
| ▸ | HTR2A | P28223 | 12/20 | 0.32 |
| ▸ | DRD3 | P35462 | 12/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949683 | 0.94 | CHRM1 (0.33) | DRD2DRD3NAMPTCHRM2CHRM4 | |
| SCHEMBL3956155 | 0.93 | DRD2 (0.35) | DRD2HTR2ADRD3ALDH1A1 | |
| SCHEMBL3950046 | 0.88 | ALDH1A1 (0.32) | DRD2HTR2ADRD3ALDH1A1 | |
| SCHEMBL3957675 | 0.87 | ALDH1A1 (0.38) | DRD2HTR2ADRD3CHRM2CHRM4 | |
| SCHEMBL3950127 | 0.85 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL3950701 | 0.85 | NAMPT (0.36) | DRD2HTR2ADRD3NAMPTALDH1A1 | |
| SCHEMBL3956742 | 0.82 | ALDH1A1 (0.39) | DRD2HTR2ADRD3ALDH1A1 | |
| SCHEMBL4044981 | 0.80 | CHRM2 (0.36) | DRD2HTR2ADRD3CHRM2CHRM4 | |
| SCHEMBL3950776 | 0.80 | ALDH1A1 (0.36) | DRD2DRD3NAMPTCHRM2CHRM4 | |
| SCHEMBL3949506 | 0.78 | ALDH1A1 (0.35) | DRD2DRD3NAMPTCHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |