Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 15/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | METAP1 | P53582 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009740 | 0.89 | METAP2 (0.51) | ATRMETAP2METAP1CBFB | |
| SCHEMBL4039745 | 0.85 | CBFB (0.47) | ATRPRKDCATMCBFB | |
| SCHEMBL4050888 | 0.83 | NPBWR1 (0.46) | ATRPDPK1CBFB | |
| SCHEMBL560241 | 0.80 | ATR (0.68) | ATRPDPK1CDK1CDK2MKNK1 | |
| SCHEMBL4046492 | 0.80 | PDE10A (0.40) | ATRCBFB | |
| SCHEMBL14969289 | 0.77 | NPC1 (0.50) | METAP2METAP1CBFB | |
| SCHEMBL560162 | 0.76 | ATR (0.60) | ATRMETAP2METAP1CBFB | |
| SCHEMBL1170649 | 0.75 | KDM4E (0.52) | METAP2METAP1CBFB | |
| SCHEMBL30612244 | 0.75 | SMN1; SMN2 (0.65) | METAP2METAP1CBFB | |
| SCHEMBL26922233 | 0.75 | SMN1; SMN2 (0.65) | METAP2METAP1CBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |