Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 14/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046492 | 0.89 | PDE10A (0.40) | CBFBKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4009740 | 0.85 | METAP2 (0.51) | CBFBATR | |
| SCHEMBL4045369 | 0.85 | ATR (0.46) | CBFBATRPRKDCATM | |
| SCHEMBL560162 | 0.79 | ATR (0.60) | CBFBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4050888 | 0.79 | NPBWR1 (0.46) | CBFBATR | |
| SCHEMBL560241 | 0.78 | ATR (0.68) | KDM4EALDH1A1HPGDHSD17B10ATR | |
| SCHEMBL1171206 | 0.75 | ALDH1A1 (0.67) | CBFBKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL38658270 | 0.69 | ALDH1A1 (0.69) | CBFBKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14278 | 0.68 | FABP6 (0.59) | CBFBKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1482507 | 0.67 | CBFB (0.56) | CBFBKDM4EALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |