Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.51 |
| ▸ | METAP1 | P53582 | 2/20 | 0.51 |
| ▸ | CBFB | Q13951 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 4/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TCF4 | P15884 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045369 | 0.89 | ATR (0.46) | METAP2METAP1CBFBATR | |
| SCHEMBL4039745 | 0.85 | CBFB (0.47) | CBFBATR | |
| SCHEMBL560162 | 0.84 | ATR (0.60) | METAP2METAP1CBFBATR | |
| SCHEMBL4006784 | 0.82 | METAP2 (0.56) | METAP2METAP1CBFBCYP11B1ATR | |
| SCHEMBL560241 | 0.80 | ATR (0.68) | ATR | |
| SCHEMBL4046492 | 0.80 | PDE10A (0.40) | CBFBATR | |
| SCHEMBL4050888 | 0.75 | NPBWR1 (0.46) | CBFBATR | |
| SCHEMBL6401549 | 0.75 | ALDH1A1 (0.65) | METAP2METAP1CBFBCYP11B1AMY1A | |
| SCHEMBL5119801 | 0.75 | CDK1 (0.64) | METAP2METAP1CBFBCYP11B1AMY1A | |
| SCHEMBL5118616 | 0.73 | CDK1 (0.77) | METAP2METAP1CBFBCYP11B1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |