Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 11/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.41 |
| ▸ | LPL | P06858 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28809490 | 0.87 | LIPG (0.43) | ELANELIPGLPLCA2HIF1A | |
| SCHEMBL25427311 | 0.86 | DGAT1 (0.41) | LIPGLPLCA2HIF1ADGAT1 | |
| SCHEMBL3451076 | 0.84 | CYP3A4 (0.50) | LIPGLPLCA2HIF1ACA1 | |
| SCHEMBL1318656 | 0.84 | ELANE (0.42) | ELANELIPGLPLCA2HIF1A | |
| SCHEMBL5761327 | 0.83 | MEN1 (0.54) | LIPGLPLCA2HIF1ACA1 | |
| SCHEMBL28469721 | 0.83 | AAK1 (0.40) | LIPGLPLCA2HIF1ADGAT1 | |
| SCHEMBL18241283 | 0.81 | LIPG (0.41) | LIPGLPLCA2HIF1ACA1 | |
| SCHEMBL29913985 | 0.81 | ACHE (0.50) | ELANELIPGLPLCA2HIF1A | |
| SCHEMBL25491942 | 0.81 | LIPG (0.41) | LIPGLPLCA2HIF1ACA1 | |
| SCHEMBL15639905 | 0.81 | ACHE (0.50) | LIPGLPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |