Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 3/20 | 0.32 |
| ▸ | MMP13 | P45452 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.30 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045086 | 0.92 | CTSK (0.42) | CTSKCTSSMMP1MMP13 | |
| SCHEMBL4040556 | 0.91 | ALDH1A1 (0.35) | CTSKCTSSP2RY12MMP1MMP13 | |
| SCHEMBL4048017 | 0.90 | CTSK (0.34) | CTSKMMP1MMP13 | |
| SCHEMBL4044695 | 0.89 | CTSK (0.36) | CTSKP2RY12MMP1MMP13 | |
| SCHEMBL6242529 | 0.89 | CTSK (0.43) | CTSKCTSSP2RY12 | |
| SCHEMBL4039018 | 0.88 | HSD17B10 (0.36) | CTSKCTSSMMP1MMP13 | |
| SCHEMBL4044587 | 0.88 | CTSK (0.35) | CTSKP2RY12 | |
| SCHEMBL4041110 | 0.87 | CTSK (0.42) | CTSKCTSS | |
| SCHEMBL4041956 | 0.85 | CTSK (0.46) | CTSKCTSSMMP1MMP13 | |
| SCHEMBL4051191 | 0.85 | CTSK (0.37) | CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |