Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.77 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688812 | 0.88 | DRD3 (1.00) | DRD3DRD2HTR1AFYNSIGMAR1 | |
| SCHEMBL28699255 | 0.84 | DRD3 (0.77) | DRD3DRD2HTR1AFYN | |
| SCHEMBL29362760 | 0.83 | DRD3 (0.75) | DRD3DRD2HTR1A | |
| SCHEMBL16299407 | 0.81 | DRD3 (0.85) | DRD3DRD2HTR1AFYNSIGMAR1 | |
| SCHEMBL11198430 | 0.78 | DRD2 (0.84) | DRD3DRD2HTR1A | |
| SCHEMBL28699254 | 0.77 | DRD3 (0.65) | DRD3DRD2HTR1A | |
| SCHEMBL31558065 | 0.77 | HTR1A (1.00) | DRD3DRD2HTR1A | |
| SCHEMBL9359278 | 0.77 | HTR1A (1.00) | DRD3DRD2HTR1A | |
| SCHEMBL11147712 | 0.76 | DRD2 (0.84) | DRD3DRD2HTR1A | |
| SCHEMBL9094473 | 0.76 | HTR1B (0.62) | DRD3DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140908-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-03-04 | — | — | EP | disclosed |
| US-6579892-B1 | Affective disorders; neurotic, stress and somatoform disorders and psychoses, e.g. schizophrenia 3-(3-(6-Methyl-1,2,3,4-tetrahydronaphth-2-ylamino)propylmercap to) -4-methyl-5-phenyl-1,2,4(4H)-triazole | ABBOTT LABORATORIES | 2003-06-17 | — | — | US | disclosed |
| EP-1140908-A1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | BASF AKTIENGESELLSCHAFT (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000042038-A1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-20 | — | — | WO | disclosed |