Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 5/20 | 0.33 |
| ▸ | CTSL | P07711 | 3/20 | 0.31 |
| ▸ | CTSS | P25774 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049692 | 0.93 | CTSK (0.37) | ELANECTSKCTSLCTSSKMT2A | |
| SCHEMBL4045340 | 0.92 | CTSK (0.40) | ELANECTSKCTSLCTSSALDH1A1 | |
| SCHEMBL4043139 | 0.90 | ELANE (0.37) | PREPFAPELANECTSKALDH1A1 | |
| SCHEMBL4046656 | 0.90 | CTSK (0.40) | CTSKCTSLCTSS | |
| SCHEMBL4044689 | 0.88 | PREP (0.35) | PREPFAPELANECTSKCTSL | |
| SCHEMBL4045026 | 0.88 | CTSK (0.36) | PREPFAPELANECTSKCTSL | |
| SCHEMBL4047831 | 0.88 | PREP (0.35) | PREPFAPELANECTSKALDH1A1 | |
| SCHEMBL4041785 | 0.88 | PREP (0.35) | PREPFAPCTSKCTSLCTSS | |
| SCHEMBL4047173 | 0.87 | SMYD3 (0.35) | PREPFAPALDH1A1 | |
| SCHEMBL4048179 | 0.87 | TSHR (0.36) | PREPFAPELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |