Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GGT1 | P19440 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318402 | 0.83 | ALDH1A1 (0.46) | TMIGD3ADORA2AKDM4EALDH1A1TSHR | |
| SCHEMBL28215142 | 0.81 | TMIGD3 (0.47) | TMIGD3ADORA2AKDM4EALDH1A1TSHR | |
| SCHEMBL8676653 | 0.80 | PTGS2 (0.61) | KDM4EALDH1A1TSHRHSD17B10ESR1 | |
| SCHEMBL28744734 | 0.80 | HPGD (0.48) | TMIGD3ADORA2AALDH1A1HPGDTDP1 | |
| SCHEMBL8379241 | 0.79 | TSHR (0.56) | TMIGD3ADORA2AKDM4EALDH1A1TSHR | |
| SCHEMBL1284485 | 0.77 | APP (0.62) | KDM4EALDH1A1HSD17B10SMN1; SMN2GAA | |
| SCHEMBL27494569 | 0.77 | ADORA2A (0.51) | TMIGD3ADORA2AKDM4EALDH1A1TSHR | |
| SCHEMBL27494568 | 0.77 | TMIGD3 (0.51) | TMIGD3ADORA2AKDM4EALDH1A1TSHR | |
| SCHEMBL9796762 | 0.76 | ADRA1D (0.48) | KDM4EALDH1A1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL9813700 | 0.74 | ALDH1A1 (0.43) | TMIGD3ADORA2AKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |