Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22729195 | 0.76 | ALOX5 (0.43) | ALOX5 | |
| SCHEMBL11816062 | 0.76 | KMT2A (0.40) | DPP4POLBGAATDP1ALDH1A1 | |
| SCHEMBL6827765 | 0.74 | ALOX5 (0.45) | ALOX5 | |
| SCHEMBL3364006 | 0.73 | ALDH1A1 (0.51) | POLBALDH1A1JAK2JAK3KMT2A | |
| SCHEMBL4046183 | 0.71 | NAAA (0.38) | MCL1DPP4CTSBCTSSCTSK | |
| SCHEMBL9427230 | 0.69 | KMT2A (0.46) | POLBGAATDP1ALDH1A1KMT2A | |
| SCHEMBL1957147 | 0.69 | ALOX5 (0.41) | ALOX5ALDH1A1KMT2AMEN1 | |
| SCHEMBL28378426 | 0.68 | ENPP2 (0.49) | ALDH1A1CTSBCTSSCTSKKMT2A | |
| SCHEMBL11716231 | 0.68 | DPP4 (0.42) | DPP4ALOX5ALDH1A1 | |
| SCHEMBL28496043 | 0.67 | ALOX5 (0.39) | ALOX5POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713815-A4 | PTH AGONISTS | SMITHKLINE BEECHAM CORP (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1713815-A1 | PTH AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005077959-A1 | PTH AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |