Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046542 | 0.93 | POLB (0.36) | CTSKALDH1A1MEN1USP2POLB | |
| SCHEMBL4045179 | 0.89 | CTSK (0.44) | CTSKPAX8CTSLCTSBCHRNA7 | |
| SCHEMBL4050939 | 0.87 | CTSK (0.37) | CTSKALDH1A1MEN1USP2POLB | |
| SCHEMBL4045083 | 0.87 | CTSK (0.47) | CTSKCTSLCTSBCHRNA7CTSS | |
| SCHEMBL4048629 | 0.86 | CTSK (0.42) | CTSKALDH1A1PAX8CTSLCTSB | |
| SCHEMBL4050440 | 0.86 | CTSK (0.43) | CTSKALDH1A1PAX8CTSLCTSB | |
| SCHEMBL4046660 | 0.85 | HTT (0.40) | CTSKALDH1A1POLBTSHRLMNA | |
| SCHEMBL4049343 | 0.85 | CTSK (0.43) | CTSKALDH1A1PAX8CTSLCTSB | |
| SCHEMBL4044450 | 0.84 | CTSK (0.43) | CTSKALDH1A1PAX8CTSLCTSB | |
| SCHEMBL4039972 | 0.83 | CTSK (0.40) | CTSKALDH1A1MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |