SCHEMBL40508

SCHEMBL40508

CCOC1C=C[CH]c2ccccc21

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.40
EYA2 O00167 1/20 0.34
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ADRA2A P08913 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
ADRA1B P35368 1/20 0.31
HTR2A P28223 1/20 0.30
HTR2C P28335 1/20 0.30
HTR2B P41595 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3957183 0.83 EYA2 (0.47) RETEYA2LMNA
SCHEMBL4516491 0.81 RET (0.42) RETLMNASMN1; SMN2ADRA2AADRA2B
SCHEMBL4630745 0.81 RET (0.37) RET
SCHEMBL290935 0.79 RET (0.36) RET
SCHEMBL8890066 0.79 TSHR (0.36) RETHTR2CHTR2B
SCHEMBL3833021 0.73 SLC6A2 (0.36) RET
SCHEMBL5970701 0.72 HTR6 (0.35) RETHTR2A
SCHEMBL8021483 0.69 HTR6 (0.33) RETLMNASMN1; SMN2ADRA2BADRA2C
SCHEMBL291732 0.69 BRD4 (0.32) RETHTR2A
SCHEMBL29434193 0.68 RET (0.44) RETEYA2LMNASMN1; SMN2ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2037762-A4 METHOD TO PREPARE PURE CURCUMIN KIM DARRICK S H L (US) 2009-07-08 EP claimed
EP-2037762-A1 METHOD TO PREPARE PURE CURCUMIN Kim, Darrick S.H.L. (US) 2009-03-25 EP claimed
WO-2007143635-A1 METHOD TO PREPARE PURE CURCUMIN KIM DARRICK S (US) 2007-12-13 WO claimed
WO-2022000071-A1 MATRIX METALLOPROTEINASE INHIBITORS (MMPIS) BRANDON UNIVERSITY (CA) 2022-01-06 WO disclosed
WO-2018158150-A1 TREATMENT OF DEMENTIA WITH CANNABINOID AGONISTS UNIVERSIDAD DEL PAÍS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) 2018-09-07 WO disclosed
WO-2018157043-A1 OXAZOUDINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR TREATING BACTERIAL INFECTIONS, INCLUDING INFECTION OF MYCOBACTERIUM TUBERCULOSIS UNIVERSITY OF ST. THOMAS (US) 2018-08-30 WO disclosed
EP-3197888-A2 NON-BETA LACTAM ANTIBIOTICS University of Notre Dame du Lac (US) 2017-08-02 EP disclosed
WO-2016090094-A1 SYNTHESIS OF CYCLOPROPYL INDOLES AND CYCLOHEPTA[B]INDOLES, PHARMECEUTICAL COMPOSITIONS CONTAINING THEM, AND METHODS AND USING THEM WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2016-06-09 WO disclosed
WO-2016049586-A2 NON-BETA LACTAM ANTIBIOTICS UNIVERSITY OF NOTRE DAME DU LAC (US) 2016-03-31 WO disclosed
WO-2015195179-A2 METAL ORGANIC FRAMEWORKS COMPRISING A PLURALITY OF SBUS WITH DIFFERENT METAL IONS AND/OR A PLURALITY OF ORGANIC LINKING LIGANDS WITH DIFFERENT FUNCTIONAL GROUPS. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-12-23 WO disclosed
WO-2015161037-A1 VERY LOW DENSITY METAL ORGANIC FRAMEWORKS WITH LARGE PORE VOLUMES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-10-22 WO disclosed
EP-0920410-A1 PREPARATION OF CYCLOHEXENE CARBOXYLATE DERIVATIVES GILEAD SCIENCES, INC. (US) 1999-06-09 EP disclosed
WO-1999014185-A1 COMPOUNDS CONTAINING SIX-MEMBERED RINGS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS GILEAD SCIENCES, INC. (US) 1999-03-25 WO disclosed
WO-1999010365-A2 5',5'-LINKED OLIGOMERS HAVING ANTI-THROMBIN ACTIVITY GILEAD SCIENCES, INC. (US) 1999-03-04 WO disclosed
WO-1998017647-A1 PIPERIDINE COMPOUNDS GILEAD SCIENCES, INC. (US) 1998-04-30 WO disclosed
WO-1998007685-A1 PREPARATION OF CYCLOHEXENE CARBOXYLATE DERIVATIVES GILEAD SCIENCES, INC. (US) 1998-02-26 WO disclosed
EP-0807118-A2 NOVEL COMPOUNDS AND METHODS FOR MAKING AND USING SAME GILEAD SCIENCES, INC. (US) 1997-11-19 EP disclosed
EP-0759917-A1 NOVEL SELECTIVE INHIBITORS OF VIRAL OR BACTERIAL NEURAMINIDASES GILEAD SCIENCES, INC. (US) 1997-03-05 EP disclosed
WO-1996026933-A9 NOVEL SELECTIVE INHIBITORS OF VIRAL OR BACTERIAL NEURAMINIDASES 1996-11-28 WO disclosed
WO-1996023801-A2 NOVEL COMPOUNDS AND METHODS FOR MAKING AND USING SAME GILEAD SCIENCES, INC. (US) 1996-08-08 WO disclosed