Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40508 | 0.81 | RET (0.40) | RET | |
| SCHEMBL3957183 | 0.76 | EYA2 (0.47) | RET | |
| SCHEMBL290935 | 0.75 | RET (0.36) | RET | |
| SCHEMBL8890066 | 0.75 | TSHR (0.36) | RET | |
| SCHEMBL3833021 | 0.69 | SLC6A2 (0.36) | RET | |
| SCHEMBL291732 | 0.65 | BRD4 (0.32) | RET | |
| SCHEMBL5970701 | 0.65 | HTR6 (0.35) | RET | |
| SCHEMBL4516491 | 0.63 | RET (0.42) | RET | |
| SCHEMBL631657 | 0.63 | HTR2A (0.31) | — | |
| SCHEMBL8021483 | 0.62 | HTR6 (0.33) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |