Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13689120 | 1.00 | EPHX2 (0.38) | EPHX2PKMKDM4EL3MBTL1RAF1 | |
| Hydrochloric Acid SCHEMBL1218441 | 0.98 | EPHX2 (0.37) | EPHX2PKMKDM4EL3MBTL1 | |
| SCHEMBL13688986 | 0.81 | ALDH1A1 (0.42) | EPHX2KDM4EL3MBTL1 | |
| SCHEMBL12898783 | 0.81 | ALDH1A1 (0.42) | EPHX2KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL1215813 | 0.80 | ALDH1A1 (0.41) | EPHX2KDM4EL3MBTL1 | |
| SCHEMBL1218374 | 0.79 | EPHX2 (0.33) | EPHX2KDM4EL3MBTL1 | |
| SCHEMBL1218951 | 0.76 | EPHX2 (0.31) | EPHX2 | |
| SCHEMBL12884853 | 0.75 | KMT2A (0.44) | L3MBTL1 | |
| SCHEMBL13689033 | 0.75 | KMT2A (0.44) | L3MBTL1 | |
| SCHEMBL12884857 | 0.75 | PKM (0.36) | PKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | CNR1, CNR2, GPR119 | EPHX2 1046/4885PKM 3544/4885KDM4E 2463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.