Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.44 |
| ▸ | DRD3 | P35462 | 7/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.38 |
| ▸ | DRD5 | P21918 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2191705 | 0.97 | HTR7 (0.44) | HTR7DRD3DRD1DRD2DRD5 | |
| SCHEMBL2197900 | 0.97 | HTR7 (0.46) | HTR7DRD3DRD1DRD2DRD5 | |
| SCHEMBL2847054 | 0.95 | HTR7 (0.41) | HTR7DRD3DRD1DRD2HTR1A | |
| SCHEMBL2194425 | 0.87 | HTR7 (0.43) | HTR7DRD3DRD1DRD2DRD5 | |
| SCHEMBL2192165 | 0.87 | HTR7 (0.46) | HTR7DRD3DRD1DRD2DRD5 | |
| SCHEMBL2194603 | 0.86 | DRD2 (0.46) | HTR7DRD3DRD1DRD2HTR1A | |
| SCHEMBL2196819 | 0.86 | HTR1A (0.46) | HTR7DRD3DRD2HTR1AADRA1D | |
| SCHEMBL2195066 | 0.86 | HTR7 (0.45) | HTR7DRD3DRD1DRD2DRD5 | |
| SCHEMBL4050945 | 0.86 | HTR7 (0.48) | HTR7DRD3DRD1DRD2DRD5 | |
| SCHEMBL2196652 | 0.85 | LMNA (0.41) | HTR7DRD3DRD1HTR1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2219648-A1 | TREATMENT OF POST-TRAUMATIC STRESS DISORDER WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | Cenomed Biosciences, LLC (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009062134-A1 | TREATMENT OF POST-TRAUMATIC STRESS DISORDER WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | CENOMED BIOSCIENCES, LLC (US) | 2009-05-14 | — | — | WO | disclosed |