Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | RXRA | P19793 | 3/20 | 0.53 |
| ▸ | RXRG | P48443 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413870 | 0.82 | PPARG (0.58) | RXRBRAB9ANPC1RXRARXRG | |
| SCHEMBL11614936 | 0.79 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23223734 | 0.79 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8811247 | 0.77 | RXRB (0.61) | RXRBRAB9ANPC1RXRARXRG | |
| SCHEMBL6142387 | 0.76 | STS (0.49) | RXRBRAB9ANPC1RXRARXRG | |
| SCHEMBL6142503 | 0.76 | HRH3 (0.46) | RXRBRAB9ANPC1RXRARXRG | |
| SCHEMBL8545870 | 0.76 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL12578070 | 0.76 | RAB9A (0.51) | RXRBRAB9ANPC1RXRARXRG | |
| SCHEMBL4056130 | 0.75 | MMP13 (0.67) | RAB9ANPC1HPGD | |
| SCHEMBL27645613 | 0.74 | RXRB (0.50) | RXRBRAB9ANPC1RXRARXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009109999-A1 | NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS | LUPIN LIMITED (IN) | 2009-09-11 | — | — | WO | disclosed |
| WO-2009109999-A1 | NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS | LUPIN LIMITED (IN) | 2009-09-11 | — | — | WO | disclosed |