Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051000 | 1.00 | RXFP1 (0.56) | RXFP1KMT2ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL4049720 | 0.78 | MAPT (0.52) | KMT2ASMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL4049726 | 0.78 | MAPT (0.52) | KMT2ASMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL5480131 | 0.75 | CYP19A1 (0.61) | GAATBXAS1ALDH1A1MAPTHTT | |
| SCHEMBL4055383 | 0.73 | ALDH1A1 (0.60) | KMT2ASMN1; SMN2L3MBTL1LMNAGAA | |
| SCHEMBL4055382 | 0.73 | ALDH1A1 (0.60) | KMT2ASMN1; SMN2L3MBTL1LMNAGAA | |
| SCHEMBL4053916 | 0.70 | ALDH1A1 (0.48) | KMT2ASMN1; SMN2L3MBTL1LMNAGAA | |
| SCHEMBL4053914 | 0.70 | ALDH1A1 (0.48) | KMT2ASMN1; SMN2L3MBTL1LMNAGAA | |
| SCHEMBL4059988 | 0.69 | POLB (0.64) | RXFP1KMT2ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL4056415 | 0.67 | CYP2C19 (0.50) | SMN1; SMN2GAAALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111260-A1 | PHENYLSULFONAMIDE-SUBSTITUTED, PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-11 | — | — | WO | disclosed |