Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049726 | 1.00 | MAPT (0.52) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL4055383 | 0.84 | ALDH1A1 (0.60) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL4055382 | 0.84 | ALDH1A1 (0.60) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL4237644 | 0.81 | ALDH1A1 (0.51) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL4237642 | 0.81 | ALDH1A1 (0.51) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL4050803 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HTTGAASMN1; SMN2RECQL | |
| SCHEMBL4056415 | 0.80 | CYP2C19 (0.50) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL4056421 | 0.80 | CYP2C19 (0.50) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL4053916 | 0.79 | ALDH1A1 (0.48) | MAPTALDH1A1HTTGAAHPGD | |
| SCHEMBL4053914 | 0.79 | ALDH1A1 (0.48) | MAPTALDH1A1HTTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111260-A1 | PHENYLSULFONAMIDE-SUBSTITUTED, PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-11 | — | — | WO | disclosed |