Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17662695 | 0.75 | PKM (0.38) | RAB9AKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4050889 | 0.75 | PKM (0.56) | RAB9AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL14045048 | 0.75 | PTGS2 (0.37) | PTGS2PTGS1SMN1; SMN2NPSR1 | |
| SCHEMBL24425229 | 0.72 | PKM (0.57) | ASIC1HDAC6KDM4EALDH1A1NR1H4 | |
| SCHEMBL3489600 | 0.71 | PTGS2 (0.55) | PTGS2PTGS1RAB9AHDAC6KDM4E | |
| SCHEMBL16141253 | 0.70 | DRD2 (0.38) | PTGS2 | |
| SCHEMBL27037831 | 0.70 | PDE4A (0.33) | — | |
| SCHEMBL24038175 | 0.70 | KIF11 (0.49) | RAB9A | |
| SCHEMBL15569210 | 0.70 | CACNB4 (0.66) | — | |
| SCHEMBL14019405 | 0.70 | MALT1 (0.41) | PTGS2PTGS1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503998-B1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SUFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME (GB) | 2009-07-01 | — | — | EP | disclosed |
| US-7435748-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2008-10-14 | — | — | US | disclosed |
| US-7435748-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2008-10-14 | — | — | US | disclosed |
| US-7427621-B2 | Cyclic sulfamides for inhibition of gamma-secretase | MERCK SHARP & DOHME LIMITED (GB) | 2008-09-23 | — | — | US | disclosed |
| US-7427621-B2 | Cyclic sulfamides for inhibition of gamma-secretase | MERCK SHARP & DOHME LIMITED (GB) | 2008-09-23 | — | — | US | disclosed |
| US-20080070895-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | COLLINS IAN J | 2008-03-20 | — | — | US | disclosed |
| US-20080070895-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | COLLINS IAN J | 2008-03-20 | — | — | US | disclosed |
| US-20080070895-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | COLLINS IAN J | 2008-03-20 | — | — | US | disclosed |
| US-7282513-B2 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-16 | — | — | US | disclosed |
| US-7282513-B2 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-16 | — | — | US | disclosed |
| US-20070088063-A1 | Gamma-secretase inhibitors | CASTRO PINEIRO JOSE L | 2007-04-19 | — | — | US | disclosed |
| US-7183303-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2007-02-27 | — | — | US | disclosed |
| US-7183303-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2007-02-27 | — | — | US | disclosed |
| US-20060264474-A1 | Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of alzheimer's disease | MERCK SHARP & DOHME LTD. (GB) | 2006-11-23 | — | — | US | disclosed |
| US-20060173054-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2006-08-03 | — | — | US | disclosed |
| US-7041689-B2 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME LTD. (GB) | 2006-05-09 | — | — | US | disclosed |
| US-20050182109-A1 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2005-08-18 | — | — | US | disclosed |
| EP-1503998-A1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SUFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME LTD. (GB) | 2005-02-09 | — | — | EP | disclosed |
| WO-2004089911-A1 | PYRAZOLE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS USEFUL IN THE TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2004-10-21 | — | — | WO | disclosed |
| WO-2003093252-A1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182109-A1 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | BACE1, BACE2, PSEN1 | PTGS2 2083/4885PTGS1 1886/4885ASIC1 4029/4885 |
| US-20060264474-A1 | Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of alzheimer's disease | BACE1, BACE2, PSEN1 | PTGS2 1447/4885PTGS1 944/4885ASIC1 4586/4885 |
| US-20060173054-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | BACE1, BACE2, PSEN1 | PTGS2 2138/4885PTGS1 1654/4885ASIC1 3703/4885 |
| US-20080070895-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | BACE1, BACE2, PSEN1 | PTGS2 2138/4885PTGS1 1654/4885ASIC1 3703/4885 |
| US-20070088063-A1 | Gamma-secretase inhibitors | BACE1, BACE2, PSEN1 | PTGS2 1603/4885PTGS1 942/4885ASIC1 4179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.