Nile Blue — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CALCRL CHRM1 CHRM2 CHRM3 F2R MAOA MAOB MAP2K1 MAP2K2 NTRK1 NTRK2 NTRK3 OPRD1 OPRK1 OPRM1 P2RY12 PKLR SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SLC18A2 SLC6A2 SLC6A3 TLR7 TLR9 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 dacA dacB dacC folA ftsI mrcA mrcB mrdA pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmB1 rpmB2 rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmH rpmI rpmJ rpmJ2 rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsR1 rpsR2 rpsS rpsT rpsU rpsZ ykgM ykgO

The experimentally established mechanism targets of Nile Blue. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	MAOB known ✓	P27338	1/20	0.38

▸	MEN1	O00255	6/20	0.71

▸	KMT2A	Q03164	6/20	0.71

▸	NPC1	O15118	2/20	0.71

▸	POLB	P06746	2/20	0.71

▸	RAB9A	P51151	2/20	0.71

▸	SCP2	P22307	1/20	0.49

▸	MAPT	P10636	5/20	0.39

▸	GAA	P10253	1/20	0.39

▸	GPR84	Q9NQS5	10/20	0.39

▸	ALDH1A1	P00352	4/20	0.38

▸	KDM4E	B2RXH2	3/20	0.38

▸	GLA	P06280	1/20	0.38

▸	L3MBTL1	Q9Y468	1/20	0.38

▸	TP53	P04637	2/20	0.37

▸	CASP1	P29466	2/20	0.37

▸	BRCA1	P38398	2/20	0.37

▸	HTT	P42858	2/20	0.37

▸	CASP7	P55210	2/20	0.37

▸	NPSR1	Q6W5P4	2/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Nile Blue SCHEMBL4051129	1.00	MEN1 (0.71)	MEN1KMT2ANPC1POLBRAB9A
Nile Blue SCHEMBL29356294	0.93	MEN1 (0.77)	MEN1KMT2ANPC1POLBRAB9A
Nile Blue SCHEMBL12393690	0.93	MEN1 (0.77)	MEN1KMT2ANPC1POLBRAB9A
SCHEMBL12393695	0.87	MEN1 (0.59)	MEN1KMT2ANPC1POLBRAB9A
Nile Red SCHEMBL49047	0.83	MEN1 (1.00)	MEN1KMT2ANPC1POLBRAB9A
Nile Red SCHEMBL29373685	0.83	MEN1 (1.00)	MEN1KMT2ANPC1POLBRAB9A
SCHEMBL23733292	0.83	MEN1 (0.58)	MEN1KMT2ANPC1POLBRAB9A
Nile Red SCHEMBL28703996	0.83	MEN1 (0.93)	MEN1KMT2ANPC1POLBRAB9A
SCHEMBL16696324	0.83	MEN1 (0.61)	MEN1KMT2ANPC1POLBRAB9A
SCHEMBL18070239	0.81	MEN1 (0.62)	MEN1KMT2ANPC1POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2024049924-A1	OPTICAL SYSTEMS AND PLATFORMS FOR SIMULTANEOUSLY ANALYZING MULTIPLE SOLUTION PROPERTIES	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US)	2024-03-07	—	—	WO	claimed
US-20260056107-A1	OPTICAL SYSTEMS AND PLATFORMS FOR SIMULTANEOUSLY ANALYZING MULTIPLE SOLUTION PROPERTIES	UNIV CALIFORNIA (US)	2026-02-26	—	—	US	disclosed
WO-2024049924-A1	OPTICAL SYSTEMS AND PLATFORMS FOR SIMULTANEOUSLY ANALYZING MULTIPLE SOLUTION PROPERTIES	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US)	2024-03-07	—	—	WO	disclosed
US-20230127982-A1	INDICATOR FILM	INSIGNIA TECHNOLOGIES LTD (GB)	2023-04-27	—	—	US	disclosed
EP-4136253-A1	ULTRA-HIGH-THROUGHPUT MICROFLUIDIC ENZYME SCREENING PLATFORM FOR ENZYME DEVELOPMENT	National University of Singapore (SG)	2023-02-22	—	—	EP	disclosed
EP-4121757-A1	INDICATOR FILM	Insignia Technologies Limited (GB)	2023-01-25	—	—	EP	disclosed
US-20220155290-A1	SYSTEMS AND METHODS FOR ENHANCED DETECTION AND QUANTIFICATION OF ANALYTES	CUE HEALTH INC. (US)	2022-05-19	—	—	US	disclosed
WO-2021209818-A1	ULTRA-HIGH-THROUGHPUT MICROFLUIDIC ENZYME SCREENING PLATFORM FOR ENZYME DEVELOPMENT	NATIONAL UNIVERSITY OF SINGAPORE (SG)	2021-10-21	—	—	WO	disclosed
US-20210318315-A1	ULTRA-HIGH-THROUGHPUT MICROFLUIDIC ENZYME SCREENING PLATFORM FOR ENZYME DEVELOPMENT	NATIONAL UNIVERSITY OF SINGAPORE (SG)	2021-10-14	—	—	US	disclosed
WO-2021186175-A1	INDICATOR FILM	INSIGNIA TECHNOLOGIES LTD (GB)	2021-09-23	—	—	WO	disclosed
US-20180329024-A1	DETECTOR FOR OPTICALLY DETECTING AT LEAST ONE OBJECT	TRINAMIX GMBH (DE)	2018-11-15	—	—	US	disclosed
EP-3380911-A1	DETECTOR FOR OPTICALLY DETECTING AT LEAST ONE OBJECT	trinamiX GmbH (DE)	2018-10-03	—	—	EP	disclosed
WO-2018140540-A1	SYSTEMS AND METHODS FOR ENHANCED DETECTION AND QUANTIFICATION OF ANALYTES	CUE HEALTH INC. (US)	2018-08-02	—	—	WO	disclosed
WO-2016045782-A1	FLUORESCENT PROTEIN STAINS	Universität Heidelberg (DE)	2016-03-31	—	—	WO	disclosed
EP-3001197-A1	Fluorescent protein stains	Universität Heidelberg (DE)	2016-03-30	—	—	EP	disclosed
WO-2009114729-A2	COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING LYSOSOMAL STORAGE DISEASES AND DISORDERS	IRM LLC (BM)	2009-09-17	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20260056107-A1	OPTICAL SYSTEMS AND PLATFORMS FOR SIMULTANEOUSLY ANALYZING MULTIPLE SOLUTION PROPERTIES	KIF11, HTT, NSF	MAOB 2104/4885MEN1 3588/4885KMT2A 3216/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.