Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065908 | 0.82 | PREP (0.56) | PREPALDH1A1GAAKDM1ARCOR1 | |
| SCHEMBL286830 | 0.82 | HTR2C (0.51) | ALDH1A1SMN1; SMN2HTR2CMEN1KMT2A | |
| SCHEMBL15409979 | 0.82 | HTR2C (0.51) | ALDH1A1SMN1; SMN2HTR2CMEN1KMT2A | |
| SCHEMBL7934107 | 0.78 | CASP1 (0.44) | PREPALDH1A1CTSLCTSBCTSK | |
| SCHEMBL4059078 | 0.77 | CHRNB2 (0.51) | KDM1A | |
| SCHEMBL5905807 | 0.76 | PREP (0.50) | PREPALDH1A1GAAKDM1ARCOR1 | |
| SCHEMBL22811402 | 0.76 | PREP (0.54) | PREPALDH1A1GAAKDM1ARCOR1 | |
| SCHEMBL2084721 | 0.76 | PREP (0.54) | PREPALDH1A1GAAKDM1ARCOR1 | |
| SCHEMBL27225255 | 0.76 | ALDH1A1 (0.51) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL11386013 | 0.75 | PREP (0.76) | PREPALDH1A1CTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |