Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869872 | 0.74 | TP53 (0.33) | HIF1ACALM1ALDH1A1TSHRTP53 | |
| Hydrochloric Acid SCHEMBL10684679 | 0.74 | HIF1A (0.30) | HIF1A | |
| Hydrochloric Acid SCHEMBL726522 | 0.57 | CALM1 (0.50) | CYP19A1CALM1HSD17B10ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL27696177 | 0.57 | — | — | |
| SCHEMBL383933 | 0.57 | CALM1 (0.50) | CALM1HSD17B10ALDH1A1TDP1TSHR | |
| SCHEMBL1244490 | 0.57 | HIF1A (0.38) | HIF1ACALM1HSD17B10ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL11775352 | 0.57 | LMNA (0.42) | HIF1ACALM1ALDH1A1KDM4ETDP1 | |
| SCHEMBL1017459 | 0.57 | HIF1A (0.46) | HIF1ACALM1HSD17B10ALDH1A1TDP1 | |
| SCHEMBL13326546 | 0.57 | HIF1A (0.58) | HIF1ACALM1HSD17B10ALDH1A1TDP1 | |
| SCHEMBL29452943 | 0.55 | CALM1 (0.63) | HIF1ACYP19A1CALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108125-A1 | GOLD NANOPARTICLES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2009-09-03 | — | — | WO | disclosed |