Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053675 | 0.86 | CYP2C19 (0.37) | KDM4EALDH1A1TSHRMCHR1CYP3A4 | |
| SCHEMBL4543729 | 0.74 | MCHR1 (0.43) | KDM4EALDH1A1TSHRMCHR1CYP3A4 | |
| SCHEMBL4057702 | 0.71 | GPR119 (0.48) | CYP3A4GPR119 | |
| SCHEMBL4048819 | 0.68 | GPR119 (0.40) | MCHR1GPR119 | |
| SCHEMBL4543839 | 0.67 | GPR119 (0.41) | KDM4EMCHR1GPR119 | |
| SCHEMBL4371632 | 0.66 | UBE2M (0.41) | TSHR | |
| SCHEMBL26149350 | 0.64 | KDM4E (0.49) | ADRA1DADRA1AADRA1BKDM4EALDH1A1 | |
| SCHEMBL4374631 | 0.63 | ITGB3 (0.40) | KDM4EALDH1A1MCHR1LTA4HGPR119 | |
| SCHEMBL13690604 | 0.62 | RXFP1 (0.41) | KDM4EALDH1A1TSHRMCHR1HSD17B10 | |
| SCHEMBL4051798 | 0.62 | SCN9A (0.39) | KDM4EALDH1A1TSHRCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |