Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GGT1 | P19440 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17167476 | 0.80 | APP (0.59) | TNFRSF1AAPPERN1KDM4EALDH1A1 | |
| SCHEMBL7639250 | 0.77 | APP (0.58) | TNFRSF1AAPPERN1TSHRHSD17B10 | |
| SCHEMBL4851399 | 0.76 | BCL2L1 (0.50) | PTGS2BCL2L1LMNACYP1A2GAA | |
| SCHEMBL19133572 | 0.75 | APP (0.57) | APPERN1BCL2L1 | |
| SCHEMBL8676653 | 0.75 | PTGS2 (0.61) | MAOBTSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL17367221 | 0.73 | SLC6A3 (0.55) | TNFRSF1AAPPERN1TSHRHSD17B10 | |
| SCHEMBL12854022 | 0.73 | APP (0.55) | APPERN1BCL2L1 | |
| SCHEMBL4048688 | 0.72 | TMIGD3 (0.58) | MAOBERN1ADORA2ATSHRKDM4E | |
| SCHEMBL17799582 | 0.72 | CA12 (0.58) | APPERN1HSD17B10ALDH1A1BCL2L1 | |
| SCHEMBL25744524 | 0.71 | APP (0.44) | TNFRSF1AAPPERN1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |