Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 7/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536055 | 0.88 | LTB4R (0.52) | LTB4R | |
| SCHEMBL12914551 | 0.76 | TP53 (0.30) | TP53ALOX15MAPK1KMT2A | |
| SCHEMBL6816923 | 0.76 | PRKCI (0.33) | KMT2A | |
| SCHEMBL14560373 | 0.75 | LTB4R (0.40) | LTB4RFFAR1ALDH1A1 | |
| SCHEMBL7217744 | 0.74 | CA2 (0.46) | LTB4R | |
| SCHEMBL7415986 | 0.73 | — | — | |
| SCHEMBL14560383 | 0.73 | CA2 (0.35) | LTB4R | |
| SCHEMBL6819727 | 0.73 | TYR (0.38) | TP53ALOX15MAPK1KMT2AALDH1A1 | |
| SCHEMBL2065835 | 0.72 | — | — | |
| SCHEMBL18826034 | 0.71 | HIF1A (0.34) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057162-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | Sepracor Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008005456-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-10 | — | — | WO | disclosed |