Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.44 |
| ▸ | BID | P55957 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054148 | 0.88 | LTB4R (0.40) | LTB4R | |
| SCHEMBL820018 | 0.80 | HIF1A (0.42) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL371668 | 0.80 | HIF1A (0.42) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL18825900 | 0.80 | HIF1A (0.42) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL10301447 | 0.80 | HIF1A (0.42) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL18826032 | 0.80 | HIF1A (0.42) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL7415986 | 0.76 | — | — | |
| SCHEMBL6819727 | 0.76 | TYR (0.38) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL14560383 | 0.76 | CA2 (0.35) | LTB4R | |
| SCHEMBL10440205 | 0.74 | LTB4R (0.52) | LTB4RSIGMAR1CES1MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528957-A4 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | — | 1993-05-05 | — | — | EP | disclosed |
| EP-0528957-A1 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-03-03 | — | — | EP | disclosed |
| WO-1991016889-A1 | FIVE-MEMBERED RING ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-11-14 | — | — | WO | disclosed |