Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7782665 | 0.74 | SIGMAR1 (0.37) | GBA1SLC6A2SLC6A4SIGMAR1 | |
| SCHEMBL16168595 | 0.71 | CHRNA7 (0.41) | GBA1SLC6A2SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL10860816 | 0.69 | SIGMAR1 (0.37) | GBA1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL3375191 | 0.69 | CHRNA7 (0.39) | GBA1SIGMAR1 | |
| SCHEMBL15749661 | 0.67 | SLC6A2 (0.38) | GBA1SLC6A2SLC6A4SLC6A3LTA4H | |
| SCHEMBL1017459 | 0.67 | HIF1A (0.46) | CHRNB4CHRNA3SIGMAR1 | |
| SCHEMBL5024201 | 0.66 | LMNA (0.33) | GBA1SLC6A2SLC6A4SLC6A3CHRM3 | |
| Bromide SCHEMBL15709541 | 0.66 | SLC6A2 (0.37) | GBA1SLC6A2SLC6A4SLC6A3LTA4H | |
| SCHEMBL6440687 | 0.65 | HIF1A (0.47) | GBA1SLC6A2SLC6A4SLC6A3CHRNB4 | |
| SCHEMBL15722779 | 0.65 | GBA1 (0.37) | GBA1SLC6A2SLC6A4SLC6A3CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069315-A2 | QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES | N.V. Organon (NL) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008033764-A2 | QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2008-03-20 | — | — | WO | disclosed |