Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 9/20 | 0.49 |
| ▸ | MGAM | O43451 | 7/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.49 |
| ▸ | SI | P14410 | 7/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10428733 | 0.88 | KCNMA1 (0.62) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL11440840 | 0.86 | KCNMA1 (0.61) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL24019555 | 0.85 | KCNMA1 (0.59) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL10428583 | 0.85 | KCNMA1 (0.59) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL1161338 | 0.82 | KCNMA1 (0.53) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL31666989 | 0.82 | KCNMA1 (0.53) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL19911475 | 0.81 | KCNMA1 (0.56) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL23638342 | 0.81 | DGAT1 (0.58) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL11294103 | 0.79 | KCNMA1 (0.57) | KCNMA1GAAMGAMAMY1ASI | |
| SCHEMBL11358890 | 0.79 | KCNMA1 (0.57) | KCNMA1GAAMGAMAMY1ASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4942248-A | CARBAMYLATION OF AMINO ACIDS BY REACTION WITH TERT-ALKYL ESTER A OF 1H-BENZOTRIAZOLE-1-CARBOXYLIC ACID TO FOR BLOCKED AMINO GROUP | PPG INDUSTRIES, INC. (US) | 1990-07-17 | — | — | US | claimed |
| EP-1392312-B1 | TRIAZOLO 4,5-d PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RES LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| US-20040097526-A1 | Triazolo[4,5-d]pyrimidine derivatives and their use as purinergic receptor antagonists | VERNALIS DEVELOPMENT LIMITED (GB) | 2004-05-20 | — | — | US | disclosed |
| US-4942248-A | CARBAMYLATION OF AMINO ACIDS BY REACTION WITH TERT-ALKYL ESTER A OF 1H-BENZOTRIAZOLE-1-CARBOXYLIC ACID TO FOR BLOCKED AMINO GROUP | PPG INDUSTRIES, INC. (US) | 1990-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097526-A1 | Triazolo[4,5-d]pyrimidine derivatives and their use as purinergic receptor antagonists | CHRNA5, CHRNA4, CNR1 | KCNMA1 1533/4885GAA 841/4885MGAM 4785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.