SCHEMBL4055323

SCHEMBL4055323

CNC(CO)c1ccccn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.44
KCNA5 P22460 5/20 0.42
KCNJ5 P48544 1/20 0.42
KCNJ3 P48549 1/20 0.42
SCN5A Q14524 1/20 0.42
KCND3 Q9UK17 1/20 0.42
KCNH2 Q12809 2/20 0.42
CYP1A2 P05177 2/20 0.41
ALDH1A1 P00352 1/20 0.41
SLC6A2 P23975 3/20 0.41
SLC6A4 P31645 3/20 0.41
SLC6A3 Q01959 2/20 0.41
CYP2D6 P10635 2/20 0.40
CYP3A4 P08684 2/20 0.40
KCNE1 P15382 1/20 0.40
CHRM2 P08172 1/20 0.39
SCN1A P35498 1/20 0.39
SCN2A Q99250 1/20 0.39
SCN3A Q9NY46 1/20 0.39
MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2323123 0.83 KCNA5 (0.47) TSHRKCNA5SCN5AKCNH2CYP1A2
SCHEMBL12259473 0.82 TSHR (0.42) TSHRKCNA5KCNJ5KCNJ3SCN5A
SCHEMBL24015882 0.80 ALDH1A1 (0.44) TSHRCYP1A2ALDH1A1SLC6A3CYP3A4
SCHEMBL24015880 0.80 ALDH1A1 (0.44) TSHRCYP1A2ALDH1A1SLC6A3CYP3A4
SCHEMBL19322907 0.80 ALDH1A1 (0.44) TSHRCYP1A2ALDH1A1SLC6A3CYP3A4
SCHEMBL9322413 0.79 KDM4E (0.51) TSHRKCNA5KCNH2CYP1A2ALDH1A1
SCHEMBL6669269 0.77 KCNA5 (0.43) TSHRKCNA5KCNJ5KCNJ3SCN5A
SCHEMBL24016451 0.77 CYP1A2 (0.39) TSHRKCNA5KCNJ5KCNJ3SCN5A
SCHEMBL27228935 0.77 ALDH1A1 (0.45) CYP1A2ALDH1A1SLC6A2SLC6A4SLC6A3
SCHEMBL19323950 0.77 ALDH1A1 (0.49) TSHRKCNA5KCNJ5KCNJ3SCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1758585-A4 HIV INTEGRASE INHIBITORS MERCK & CO INC (US) 2009-07-22 EP disclosed
EP-1758585-A2 HIV INTEGRASE INHIBITORS Merck & Co., Inc. (US) 2007-03-07 EP disclosed
WO-2005120516-A2 HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 2005-12-22 WO disclosed
EP-1472260-A2 THIENO(3,2-B)PYRIDONES AS ANTIVIRAL COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 2004-11-03 EP disclosed
WO-2003059878-A2 THIENO (3, 2-B) PYRIDONES AS ANTIVIRAL COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 2003-07-24 WO disclosed