SCHEMBL6669269

SCHEMBL6669269

CNC(c1ccccn1)C(O)CO

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 5/20 0.43
KCNJ5 P48544 1/20 0.43
KCNJ3 P48549 1/20 0.43
SCN5A Q14524 1/20 0.43
KCND3 Q9UK17 1/20 0.43
TSHR P16473 1/20 0.41
SLC6A2 P23975 3/20 0.41
SLC6A4 P31645 3/20 0.41
KCNH2 Q12809 2/20 0.41
SLC6A3 Q01959 2/20 0.41
CYP2D6 P10635 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP1A2 P05177 2/20 0.39
ALDH1A1 P00352 1/20 0.39
KDM4E B2RXH2 1/20 0.38
SLC10A1 Q14973 2/20 0.38
KCNE1 P15382 1/20 0.37
TP53 P04637 1/20 0.37
CHRM2 P08172 1/20 0.36
SCN1A P35498 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4055323 0.77 TSHR (0.44) KCNA5KCNJ5KCNJ3SCN5AKCND3
SCHEMBL13400117 0.77 SLC6A2 (0.44) KCNA5TSHRSLC6A2SLC6A4KCNH2
SCHEMBL21433089 0.77 SLC6A2 (0.44) KCNA5TSHRSLC6A2SLC6A4KCNH2
SCHEMBL6673374 0.77 KDM4E (0.39) CYP3A4ALDH1A1KDM4ESMN1; SMN2
SCHEMBL15830186 0.74 SLC6A3 (0.45) KCNA5TSHRSLC6A2SLC6A4KCNH2
SCHEMBL30663811 0.72 SLC6A2 (0.47) KCNA5KCNJ5KCNJ3SCN5AKCND3
SCHEMBL211788 0.72 SLC6A2 (0.47) KCNA5KCNJ5KCNJ3SCN5AKCND3
SCHEMBL6481541 0.72 SLC6A2 (0.47) KCNA5KCNJ5KCNJ3SCN5AKCND3
SCHEMBL10438505 0.72 TSHR (0.40) KCNA5KCNJ5KCNJ3SCN5AKCND3
SCHEMBL14928678 0.71 TSHR (0.48) KCNA5KCNJ5KCNJ3SCN5AKCND3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1066286-A4 HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2004-02-11 EP disclosed
EP-1066286-A1 HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-01-10 EP disclosed
WO-1999045009-A1 HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-09-10 WO disclosed