Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 3/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988982 | 0.87 | NOTUM (0.39) | LMNAMAPTHTTBLMMEN1 | |
| SCHEMBL991392 | 0.83 | NOTUM (0.50) | LMNAMAPTHTTBLMMEN1 | |
| SCHEMBL4109996 | 0.81 | NOTUM (0.50) | LMNAMAPTHTTBLMGAA | |
| SCHEMBL989938 | 0.80 | ALDH1A1 (0.41) | LMNAMEN1NPC1GAARAB9A | |
| SCHEMBL989368 | 0.78 | ALDH1A1 (0.38) | LMNAMAPTMEN1NPC1GAA | |
| SCHEMBL989371 | 0.77 | KDM4E (0.41) | LMNAMAPTMEN1NPC1GAA | |
| SCHEMBL1516838 | 0.76 | SRD5A1 (0.38) | LMNAMAPTHTTBLMGAA | |
| SCHEMBL988065 | 0.73 | THRB (0.42) | LMNAMAPTMEN1NPC1GAA | |
| SCHEMBL988659 | 0.69 | NOTUM (0.53) | LMNAMEN1GAAKMT2APIK3CA | |
| SCHEMBL1484681 | 0.68 | MAP3K14 (0.51) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |