Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988662 | 0.85 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDTDP1L3MBTL1 | |
| SCHEMBL988679 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1HPGDTDP1L3MBTL1 | |
| SCHEMBL988982 | 0.82 | NOTUM (0.39) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL991392 | 0.81 | NOTUM (0.50) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL989938 | 0.81 | ALDH1A1 (0.41) | KDM4EALDH1A1NPC1RAB9AGAA | |
| SCHEMBL1484646 | 0.80 | MAP3K14 (0.48) | NPC1RAB9ACLK1OGA | |
| SCHEMBL4055690 | 0.77 | LMNA (0.36) | KDM4EALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL1484604 | 0.73 | PIK3CA (0.42) | NPC1RAB9ACLK1OGA | |
| SCHEMBL1516838 | 0.72 | SRD5A1 (0.38) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL16794102 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1HPGDTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |