Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 8/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048840 | 0.92 | KIF11 (0.39) | KIF11GNRHRBRD4DYRK1ASIGMAR1 | |
| SCHEMBL4051691 | 0.82 | KIF11 (0.53) | KIF11KCNH2 | |
| SCHEMBL4050591 | 0.82 | KIF11 (0.41) | KIF11GNRHRBRD4SIGMAR1ADORA2A | |
| SCHEMBL4055834 | 0.82 | KIF11 (0.41) | KIF11GNRHRBRD4SIGMAR1ADORA2A | |
| SCHEMBL13963456 | 0.81 | SIGMAR1 (0.42) | KIF11GNRHRBRD4SIGMAR1 | |
| SCHEMBL4056718 | 0.80 | KIF11 (0.41) | KIF11BRD4TLR7 | |
| SCHEMBL4056720 | 0.80 | KIF11 (0.41) | KIF11BRD4TLR7 | |
| SCHEMBL4049089 | 0.80 | KIF11 (0.39) | KIF11GNRHRBRD4SIGMAR1TLR7 | |
| SCHEMBL4056075 | 0.79 | KIF11 (0.40) | KIF11GNRHRBRD4SIGMAR1TLR7 | |
| SCHEMBL4056076 | 0.79 | KIF11 (0.40) | KIF11GNRHRBRD4SIGMAR1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070932-A1 | Pyrazolotriazines | 4SC AG (DE) | 2009-06-17 | — | — | EP | disclosed |