Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | STAT1 | P42224 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050015 | 0.85 | ELANE (0.49) | HIF1ASCN9AELANE | |
| SCHEMBL4056135 | 0.78 | STAT1 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL9024249 | 0.77 | ALDH1A1 (0.57) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL7421574 | 0.74 | SCN9A (0.58) | TSHRSCN9ASTAT1RORCALDH1A1 | |
| SCHEMBL30572213 | 0.69 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL9484257 | 0.69 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL9025523 | 0.69 | RORC (0.56) | NPSR1SCN9ASTAT1RORCKMT2A | |
| SCHEMBL27758519 | 0.69 | ELANE (0.57) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL15420907 | 0.68 | HTR3A (0.53) | SCN9ASTAT1RORC | |
| SCHEMBL5742862 | 0.67 | OXER1 (0.41) | KMT2AALDH1A1POLBTHRBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |