Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AGER | Q15109 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056206 | 0.99 | ENPP2 (0.52) | ENPP2SIGMAR1TSHRALDH1A1EPHX1 | |
| SCHEMBL21872794 | 0.84 | ENPP2 (0.60) | ENPP2SIGMAR1TSHRALDH1A1EPHX1 | |
| SCHEMBL28378426 | 0.81 | ENPP2 (0.49) | ENPP2SIGMAR1TSHRALDH1A1EPHX1 | |
| SCHEMBL1008555 | 0.80 | ENPP2 (0.56) | ENPP2SIGMAR1TSHRALDH1A1EPHX1 | |
| SCHEMBL4205099 | 0.80 | SIGMAR1 (0.63) | ENPP2SIGMAR1TSHRALDH1A1MEN1 | |
| SCHEMBL24397539 | 0.79 | ENPP2 (0.45) | ENPP2SIGMAR1TSHRALDH1A1L3MBTL1 | |
| SCHEMBL22460342 | 0.79 | ENPP2 (0.45) | ENPP2SIGMAR1TSHRALDH1A1L3MBTL1 | |
| SCHEMBL8029227 | 0.78 | SIGMAR1 (0.64) | ENPP2SIGMAR1TSHRALDH1A1MEN1 | |
| SCHEMBL3564278 | 0.78 | ENPP2 (0.54) | ENPP2SIGMAR1TSHRALDH1A1EPHX1 | |
| SCHEMBL13684267 | 0.78 | L3MBTL1 (0.63) | ENPP2SIGMAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081919-A1 | TETRAHYDROFURO [3, 2-B]PYRR0L-3-0NE INTERMEDIATES | Amura Therapeutics Limited (GB) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008007132-A1 | TETRAHYDROFURO [3, 2-B] PYRR0L-3-0NE INTERMEDIATES | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007112-A1 | TETRAHYDROFURO [3, 2-B] PYRR0L-3-ONES AS CATHEPSIN K INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |