Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3564278 | 0.98 | ENPP2 (0.54) | ENPP2SIGMAR1ALDH1A1EPHX1KMT2A | |
| SCHEMBL21872794 | 0.86 | ENPP2 (0.60) | ENPP2SIGMAR1ALDH1A1EPHX1MEN1 | |
| SCHEMBL4205099 | 0.82 | SIGMAR1 (0.63) | ENPP2SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL29068551 | 0.81 | ENPP2 (0.52) | ENPP2SIGMAR1TSHRL3MBTL1TRPM8 | |
| SCHEMBL6193454 | 0.81 | ENPP2 (0.52) | ENPP2SIGMAR1ALDH1A1EPHX1TSHR | |
| SCHEMBL8029227 | 0.81 | SIGMAR1 (0.64) | ENPP2SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL190556 | 0.80 | ENPP2 (0.57) | ENPP2SIGMAR1ALDH1A1EPHX1L3MBTL1 | |
| SCHEMBL22285161 | 0.80 | ENPP2 (0.57) | ENPP2SIGMAR1ALDH1A1EPHX1L3MBTL1 | |
| SCHEMBL13684267 | 0.80 | L3MBTL1 (0.63) | ENPP2SIGMAR1L3MBTL1 | |
| SCHEMBL4056164 | 0.80 | ENPP2 (0.54) | ENPP2SIGMAR1ALDH1A1EPHX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464634-B1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2016-11-30 | — | — | EP | disclosed |
| US-8933227-B2 | Selective synthesis of functionalized pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-01-13 | — | — | US | disclosed |
| US-20140213787-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-31 | — | — | US | disclosed |
| US-8729265-B2 | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-20 | — | — | US | disclosed |
| US-20130079519-A1 | REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES | DURAN ADIL (DE) | 2013-03-28 | — | — | US | disclosed |
| US-8334383-B2 | Regioselective preparation of substituted pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-12-18 | — | — | US | disclosed |
| US-20120172596-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-05 | — | — | US | disclosed |
| US-20110190499-A1 | SELECTIVE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-04 | — | — | US | disclosed |
| US-20110077403-A1 | REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-31 | — | — | US | disclosed |
| EP-2268622-A1 | REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES | Boehringer Ingelheim International GmbH (DE) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009115587-A1 | REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190499-A1 | SELECTIVE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES | DPYD, TYMS, UMPS | ENPP2 2461/4885SIGMAR1 3346/4885ALDH1A1 727/4885 |
| US-20140213787-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | DPYD, CYP3A5, PAICS | ENPP2 2121/4885SIGMAR1 3784/4885ALDH1A1 172/4885 |
| US-20110077403-A1 | REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES | TYMS, DPYD, TYMP | ENPP2 2350/4885SIGMAR1 2773/4885ALDH1A1 751/4885 |
| US-20120172596-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | DPYD, HRH2, TYMS | ENPP2 2645/4885SIGMAR1 1022/4885ALDH1A1 1048/4885 |
| US-20130079519-A1 | REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES | TYMS, DPYD, TYMP | ENPP2 2241/4885SIGMAR1 2596/4885ALDH1A1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.