SCHEMBL4056341

SCHEMBL4056341

C=CCOc1cc(O)c2c(=O)cc(-c3ccccc3)oc2c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.72
ABCB1 P08183 4/20 0.72
EGFR P00533 1/20 0.72
RET P07949 1/20 0.72
KDR P35968 1/20 0.72
MAOA P21397 3/20 0.71
MAOB P27338 3/20 0.71
CYP1A1 P04798 2/20 0.68
CYP1A2 P05177 2/20 0.68
NPSR1 Q6W5P4 1/20 0.67
CYP3A4 P08684 2/20 0.66
CYP2C9 P11712 2/20 0.66
CYP2C19 P33261 2/20 0.66
ABCG2 Q9UNQ0 2/20 0.66
NPC1 O15118 1/20 0.66
TSHR P16473 1/20 0.66
KDM4E B2RXH2 2/20 0.64
MEN1 O00255 1/20 0.64
GABRP O00591 1/20 0.64
GABRD O14764 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4225411 0.87 PPARG (0.73) MAPTABCB1EGFRRETKDR
SCHEMBL29494586 0.86 PPARG (0.80) MAPTABCB1EGFRRETKDR
SCHEMBL21236746 0.86 PPARG (0.80) MAPTABCB1EGFRRETKDR
SCHEMBL4153258 0.85 MAOB (0.72) MAPTABCB1EGFRRETKDR
SCHEMBL30376285 0.84 MAPT (1.00) MAPTABCB1EGFRRETKDR
SCHEMBL10025658 0.84 MAPT (0.77) MAPTABCB1EGFRRETKDR
SCHEMBL974548 0.84 MAPT (1.00) MAPTABCB1EGFRRETKDR
SCHEMBL8308052 0.83 MAOB (0.67) MAPTABCB1EGFRRETKDR
SCHEMBL4575435 0.82 CYP1B1 (0.71) MAPTKDRMAOAMAOBCYP1A1
SCHEMBL8391032 0.82 EGFR (0.74) MAPTABCB1EGFRRETKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009110008-A1 ANTI-ULCER ACTIVITY OF FLAVONE ANALOGS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2009-09-11 WO disclosed