SCHEMBL8308052

SCHEMBL8308052

C=CCOc1cc(O)c2c(=O)cc(-c3ccc(OC)cc3)oc2c1.CC=CO

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.67
MAOA P21397 4/20 0.67
CYP19A1 P11511 1/20 0.67
MAPT P10636 4/20 0.64
FLT3 P36888 3/20 0.64
NPC1 O15118 3/20 0.64
IP6K2 Q9UHH9 2/20 0.64
CYP3A4 P08684 2/20 0.64
CYP2C9 P11712 2/20 0.64
CYP2C19 P33261 2/20 0.64
MEN1 O00255 2/20 0.64
RAB9A P51151 2/20 0.64
KMT2A Q03164 2/20 0.64
USP2 O75604 1/20 0.64
ALDH1A1 P00352 1/20 0.64
LMNA P02545 1/20 0.64
TP53 P04637 1/20 0.64
CYP1A1 P04798 1/20 0.64
CYP1A2 P05177 1/20 0.64
CYP2D6 P10635 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8305728 0.89 MAOB (0.66) MAOBMAOACYP19A1MAPTFLT3
Acacetin SCHEMBL8309340 0.86 CYP1B1 (0.86) MAOBMAOACYP19A1MAPTFLT3
SCHEMBL8429597 0.86 XDH (0.70) MAOBMAOACYP19A1MAPTFLT3
SCHEMBL4153258 0.86 MAOB (0.72) MAOBMAOACYP19A1MAPTFLT3
SCHEMBL8305040 0.85 MAPT (0.73) MAOBMAOACYP19A1MAPTFLT3
SCHEMBL4575435 0.84 CYP1B1 (0.71) MAOBMAOACYP19A1MAPTFLT3
SCHEMBL4056341 0.83 MAPT (0.72) MAOBMAOACYP19A1MAPTNPC1
SCHEMBL8304836 0.83 CYP1B1 (0.66) MAOBMAOACYP19A1MAPTFLT3
SCHEMBL8429204 0.83 MAOB (0.62) MAOBMAOACYP19A1MAPTFLT3
Apigenin Dimethylether SCHEMBL29392759 0.81 MAOB (1.00) MAOBMAOACYP19A1MAPTFLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0709383-B1 Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them ADIR (FR) 1999-12-15 EP disclosed
EP-0709383-A1 Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1996-05-01 EP disclosed