Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 11/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | LIPE | Q05469 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31370464 | 0.88 | NAMPT (0.57) | DGAT1HMOX1NAMPTGPR119LIPE | |
| SCHEMBL18421955 | 0.83 | NAMPT (0.47) | NAMPTGPR119LIPE | |
| SCHEMBL5318377 | 0.83 | MMP1 (0.52) | NAMPTGPR119LIPEEPHX2 | |
| SCHEMBL16973181 | 0.83 | NAMPT (0.45) | NAMPTGPR119LIPEEPHX2 | |
| SCHEMBL4107104 | 0.83 | LIPE (0.49) | NAMPTGPR119LIPEEPHX2 | |
| SCHEMBL30427128 | 0.82 | GPR119 (0.66) | DGAT1GPR119 | |
| SCHEMBL940648 | 0.82 | GPR119 (0.66) | DGAT1GPR119 | |
| SCHEMBL865755 | 0.82 | GPR119 (0.58) | DGAT1NAMPTGPR119 | |
| SCHEMBL18423411 | 0.82 | NAMPT (0.47) | NAMPTGPR119LIPEEPHX2 | |
| SCHEMBL2775875 | 0.81 | HMOX1 (0.60) | HMOX1GPR119EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105225-A1 | NOVEL 3-(INDOL-3-YL)-PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | iTeos Therapeutics (BE) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015121812-A1 | NOVEL 3-(INDOL-3-YL)-PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2015-08-20 | — | — | WO | disclosed |
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| EP-1676846-A2 | Hydantoin derivatives as MMP inhibitors | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |