Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | IKBKB | O14920 | 1/20 | 0.71 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.67 |
| ▸ | TUBB | P07437 | 4/20 | 0.67 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.67 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.67 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.67 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.67 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.67 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.67 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.67 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.67 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.67 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.67 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3768095 | 0.90 | ADORA1 (0.81) | ADORA1GAAALDH1A1HPGDMEN1 | |
| SCHEMBL1062225 | 0.84 | GAA (1.00) | ADORA1GAAALDH1A1HPGDMEN1 | |
| SCHEMBL3510525 | 0.83 | IKBKB (1.00) | ADORA1GAAALDH1A1HPGDMEN1 | |
| SCHEMBL15960089 | 0.81 | GAA (0.75) | ADORA1GAAALDH1A1HPGDMEN1 | |
| SCHEMBL7057166 | 0.81 | GAA (0.75) | ADORA1GAAALDH1A1HPGDMEN1 | |
| Formamide SCHEMBL28359882 | 0.79 | GAA (0.87) | ADORA1GAAALDH1A1HPGDMEN1 | |
| SCHEMBL8288757 | 0.78 | MAPT (0.76) | ADORA1GAAALDH1A1HPGDMEN1 | |
| SCHEMBL4061364 | 0.78 | ADORA1 (0.64) | ADORA1GAAALDH1A1HPGDMEN1 | |
| SCHEMBL1563613 | 0.78 | GAA (1.00) | ADORA1GAAALDH1A1HPGDMEN1 | |
| SCHEMBL7058046 | 0.76 | GAA (0.73) | ADORA1GAAALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101120003-B | Thieno-pyridine derivatives as GABA-B allosteric enhancers | HOFFMANN LA ROCHE | 2010-06-16 | — | — | CN | disclosed |
| EP-1828199-B1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | EP | disclosed |
| US-7390903-B2 | Thieno-pyridine derivatives as allosteric enhancers of the GABAB receptors | HOFFMANN-LA ROCHE INC. (US) | 2008-06-24 | — | — | US | disclosed |
| CN-101120003-A | Thieno-pyridine derivatives as GABA-B allosteric enhancers | HOFFMANN LA ROCHE (CH) | 2008-02-06 | — | — | CN | disclosed |
| EP-1828199-A1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | F. Hoffmann-Roche AG (CH) | 2007-09-05 | — | — | EP | disclosed |
| US-20060135552-A1 | Thieno-pyridine derivatives as allosteric enhancers of the GABAB receptors | HOFFMANN-LA ROCHE INC. | 2006-06-22 | — | — | US | disclosed |
| WO-2006063732-A1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135552-A1 | Thieno-pyridine derivatives as allosteric enhancers of the GABAB receptors | GABBR1, CHRNA5, CHRNA3 | ADORA1 127/4885GAA 1934/4885ALDH1A1 3097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.