Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | CDC42 | P60953 | 1/20 | 0.44 |
| ▸ | RAC1 | P63000 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5350347 | 0.84 | F10 (0.53) | KDM4ECYP1A2F10MAPTSMN1; SMN2 | |
| SCHEMBL13783465 | 0.82 | KDM4E (0.43) | KDM4EAKR1C3AKR1C2PTGS1HSD17B1 | |
| SCHEMBL5752975 | 0.79 | KDM4E (0.46) | KDM4EAKR1C3AKR1C2PTGS1HSD17B1 | |
| SCHEMBL27094015 | 0.79 | PTPN1 (0.46) | KDM4EAKR1C3AKR1C2CYP1A2MAPT | |
| SCHEMBL4064596 | 0.78 | F10 (0.47) | KDM4EHSD17B1HSD17B2CYP1A2F10 | |
| SCHEMBL4064359 | 0.76 | NPC1 (0.57) | KDM4EAKR1C3AKR1C2PTGS1CYP1A2 | |
| SCHEMBL4058023 | 0.76 | NPC1 (0.56) | KDM4EAKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL6117229 | 0.74 | RAB9A (0.61) | KDM4EF10TSHRMAPTNPC1 | |
| SCHEMBL3704664 | 0.74 | GAA (0.61) | AKR1C3AKR1C2F10MAPTSMN1; SMN2 | |
| SCHEMBL3100581 | 0.72 | SLC16A3 (0.64) | KDM4ECYP1A2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090182001-A1 | Inhibitors of checkpoint kinases | MERCK SHARP & DOHME CORP. | 2009-07-16 | — | — | US | disclosed |
| EP-1910365-A4 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1910365-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015837-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182001-A1 | Inhibitors of checkpoint kinases | CHEK1, CHEK2, BUB1B | KDM4E 850/4885AKR1C3 3501/4885AKR1C2 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.