Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752975 | 0.90 | KDM4E (0.46) | F10NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL13783464 | 0.82 | NR1I2 (0.42) | F10MTNR1ANPC1LMNARAB9A | |
| SCHEMBL5350347 | 0.80 | F10 (0.53) | F10NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4057189 | 0.78 | KDM4E (0.49) | F10NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL6086928 | 0.76 | ALDH1A1 (0.50) | MTNR1ALMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6117229 | 0.76 | RAB9A (0.61) | F10NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17796966 | 0.74 | POLB (0.62) | F10NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL5833241 | 0.74 | ALDH1A1 (0.73) | NPC1LMNARAB9ASMN1; SMN2AHR | |
| SCHEMBL978331 | 0.73 | GAA (0.49) | F10NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2095013 | 0.73 | RAB9A (0.58) | F10NPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090182001-A1 | Inhibitors of checkpoint kinases | MERCK SHARP & DOHME CORP. | 2009-07-16 | — | — | US | disclosed |
| EP-1910365-A4 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1910365-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015837-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182001-A1 | Inhibitors of checkpoint kinases | CHEK1, CHEK2, BUB1B | F10 4555/4885MTNR1A 4579/4885NPC1 3878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.