SCHEMBL4057372

SCHEMBL4057372

CC(Cl)n1cnc2nc(N)[nH]c(=O)c21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 0.41
HSD17B10 Q99714 2/20 0.40
THRB P10828 2/20 0.40
HPGD P15428 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
CYP1A2 P05177 1/20 0.38
AKR1B1 P15121 3/20 0.36
ADORA2A P29274 1/20 0.36
ADORA1 P30542 1/20 0.36
NOS1 P29475 1/20 0.36
TYMS P04818 1/20 0.36
MITF O75030 1/20 0.36
TP53 P04637 1/20 0.36
ALOX15 P16050 1/20 0.36
HBB P68871 1/20 0.36
HIF1A Q16665 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19413462 0.88 ADORA2A (0.49) PNPHSD17B10THRBHPGDKDM4E
SCHEMBL4058210 0.85 HSD17B10 (0.45) PNPHSD17B10THRBHPGDKDM4E
SCHEMBL48266 0.81 AKR1B1 (0.44) PNPHSD17B10THRBHPGDKDM4E
SCHEMBL6528880 0.79 HSD17B10 (0.41) PNPHSD17B10THRBHPGDKDM4E
SCHEMBL25547 0.78 GDA (0.49) PNPHSD17B10THRBHPGDKDM4E
SCHEMBL455760 0.77 HPGD (0.41) PNPHSD17B10THRBHPGDKDM4E
SCHEMBL4364146 0.76 BLM (0.39) PNPHSD17B10MEN1ALDH1A1KMT2A
SCHEMBL28955037 0.76 PNP (0.46) PNPHSD17B10THRBHPGDKDM4E
SCHEMBL3260925 0.74 PNP (0.45) PNPHSD17B10THRBHPGDKDM4E
SCHEMBL9818039 0.74 PNP (0.45) PNPHSD17B10THRBHPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180258474-A1 METHODS FOR DETERMINING BASE LOCATIONS IN A POLYNUCLEOTIDE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-09-13 US claimed
EP-1419247-B1 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS DIREVO BIOTECH AG (DE) 2006-09-20 EP claimed
US-20050130142-A1 Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids DIREVO BIOTECH AG (DE) 2005-06-16 US claimed
EP-1419247-A2 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS Direvo Biotech AG (DE) 2004-05-19 EP claimed
WO-2003012100-A2 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS DIREVO BIOTECH AG (DE) 2003-02-13 WO claimed
EP-1281757-A1 Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids Direvo Biotech AG (DE) 2003-02-05 EP claimed
US-20230095192-A1 SYNTHETIC AGONISTS OF DNA-PK AND THEIR USE UNIVERSITY OF WASHINGTON 2023-03-30 US disclosed
US-20210071239-A1 METHODS FOR DETERMINING BASE LOCATIONS IN A POLYNUCLEOTIDE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-03-11 US disclosed
US-10760117-B2 Methods for determining base locations in a polynucleotide THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-09-01 US disclosed
US-20180258474-A1 METHODS FOR DETERMINING BASE LOCATIONS IN A POLYNUCLEOTIDE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-09-13 US disclosed
EP-3280793-A1 METHODS FOR DETERMINING BASE LOCATIONS IN A POLYNUCLEOTIDE The Regents of the University of California (US) 2018-02-14 EP disclosed
WO-2016164363-A1 METHODS FOR DETERMING BASE LOCATIONS IN A POLYNUCLEOTIDE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-10-13 WO disclosed
WO-2009121021-A1 DEGRADABLE ARRAYS FOR PREVENTING REUSE Life Technologies Corporation (US) 2009-10-01 WO disclosed
WO-2009121028-A1 COMPOSITIONS AND METHODS FOR REUSING ARRAYS Life Technologies Corporation (US) 2009-10-01 WO disclosed
US-20090247425-A1 COMPOSITIONS AND METHODS FOR REUSING ARRAYS INVITROGEN CORPORATION (US) 2009-10-01 US disclosed
EP-1419247-B1 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS DIREVO BIOTECH AG (DE) 2006-09-20 EP disclosed
US-20050130142-A1 Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids DIREVO BIOTECH AG (DE) 2005-06-16 US disclosed
EP-1419247-A2 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS Direvo Biotech AG (DE) 2004-05-19 EP disclosed
WO-2003012100-A2 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS DIREVO BIOTECH AG (DE) 2003-02-13 WO disclosed
EP-1281757-A1 Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids Direvo Biotech AG (DE) 2003-02-05 EP disclosed