SCHEMBL4058210

SCHEMBL4058210

CC(O)n1cnc2nc(N)[nH]c(=O)c21

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.45
PNP P00491 2/20 0.41
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
THRB P10828 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
AKR1B1 P15121 4/20 0.39
CYP1A2 P05177 1/20 0.38
HPRT1 P00492 2/20 0.38
ADORA2A P29274 1/20 0.36
ADORA1 P30542 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6528880 0.93 HSD17B10 (0.41) HSD17B10PNPKDM4EMEN1ALDH1A1
SCHEMBL19413462 0.88 ADORA2A (0.49) HSD17B10PNPKDM4EMEN1ALDH1A1
SCHEMBL4057372 0.85 PNP (0.41) HSD17B10PNPKDM4EMEN1ALDH1A1
SCHEMBL48266 0.84 AKR1B1 (0.44) HSD17B10PNPKDM4EMEN1ALDH1A1
SCHEMBL4364146 0.79 BLM (0.39) HSD17B10PNPMEN1ALDH1A1KMT2A
SCHEMBL6455102 0.78 HPRT1 (0.56) HSD17B10PNPMEN1ALDH1A1KMT2A
SCHEMBL25547 0.78 GDA (0.49) HSD17B10PNPKDM4EMEN1ALDH1A1
SCHEMBL9818039 0.78 PNP (0.45) HSD17B10PNPKDM4EMEN1ALDH1A1
SCHEMBL455760 0.77 HPGD (0.41) HSD17B10PNPKDM4EMEN1ALDH1A1
SCHEMBL8884722 0.76 TK1 (0.42) HSD17B10PNPMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1419247-B1 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS DIREVO BIOTECH AG (DE) 2006-09-20 EP claimed
EP-1419247-A2 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS Direvo Biotech AG (DE) 2004-05-19 EP claimed
WO-2003012100-A2 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS DIREVO BIOTECH AG (DE) 2003-02-13 WO claimed
EP-1281757-A1 Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids Direvo Biotech AG (DE) 2003-02-05 EP claimed
WO-2009121021-A1 DEGRADABLE ARRAYS FOR PREVENTING REUSE Life Technologies Corporation (US) 2009-10-01 WO disclosed
WO-2009121028-A1 COMPOSITIONS AND METHODS FOR REUSING ARRAYS Life Technologies Corporation (US) 2009-10-01 WO disclosed
US-20090247425-A1 COMPOSITIONS AND METHODS FOR REUSING ARRAYS INVITROGEN CORPORATION (US) 2009-10-01 US disclosed
EP-1419247-B1 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS DIREVO BIOTECH AG (DE) 2006-09-20 EP disclosed
US-20050130142-A1 Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids DIREVO BIOTECH AG (DE) 2005-06-16 US disclosed
EP-1419247-A2 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS Direvo Biotech AG (DE) 2004-05-19 EP disclosed
WO-2003012100-A2 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS DIREVO BIOTECH AG (DE) 2003-02-13 WO disclosed
EP-1281757-A1 Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids Direvo Biotech AG (DE) 2003-02-05 EP disclosed