SCHEMBL4058172

SCHEMBL4058172

CO[Si]([O])(CCCc1ccccc1)OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.42
HDAC3 O15379 1/20 0.42
MAPK1 P28482 1/20 0.42
ADRA1A P35348 1/20 0.42
HDAC4 P56524 1/20 0.42
SLC6A3 Q01959 1/20 0.42
HDAC1 Q13547 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
CES1 P23141 1/20 0.42
KMT2A Q03164 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2822247 0.80 IDO1 (0.45) IDO1KMT2AL3MBTL1MEN1ALDH1A1
SCHEMBL9716586 0.80 MAOA (0.48) IDO1ADRA1ASLC6A3KMT2AL3MBTL1
SCHEMBL3342170 0.78 IDO1 (0.44) IDO1ADRA1ASLC6A3CES1KMT2A
SCHEMBL1068905 0.78 IDO1 (0.44) IDO1ADRA1ASLC6A3CES1KMT2A
SCHEMBL4494440 0.78 ADRA1A (0.47) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL22283490 0.77 HDAC3 (0.50) IDO1HDAC3MAPK1ADRA1AHDAC4
SCHEMBL4058177 0.77 IDO1 (0.42) IDO1HDAC3MAPK1ADRA1AHDAC4
SCHEMBL29040556 0.76 MAOA (0.44) IDO1ADRA1ASLC6A3CES1KMT2A
SCHEMBL2748794 0.74 L3MBTL1 (0.47) IDO1L3MBTL1SIGMAR1MAOA
SCHEMBL18979278 0.73 L3MBTL1 (0.49) CES1L3MBTL1SIGMAR1MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1863875-B1 SELF-ADHESIVE ADDITION CROSS LINKING SILICON-RUBBER BLENDS, METHOD FOR THE PRODUCTION THEREOF, METHOD FOR PRODUCING COMPOSITE MOULDED PARTS AND THE USE THEREOF MOMENTIVE PERFORMANCE MAT INC (DE) 2009-12-09 EP claimed
US-20090068475-A1 Self-Adhesive Addition-Crosslinking Silicon Rubber Blends, A Method For The Production Thereof, Methods For Producing Composite Moulded Parts And The Use Thereof MOMENTIVE PERFORMANCE MATERIALS GMBH (DE) 2009-03-12 US claimed
US-20090068475-A1 Self-Adhesive Addition-Crosslinking Silicon Rubber Blends, A Method For The Production Thereof, Methods For Producing Composite Moulded Parts And The Use Thereof MOMENTIVE PERFORMANCE MATERIALS GMBH (DE) 2009-03-12 US disclosed