Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052271 | 0.84 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4047830 | 0.77 | MAPT (0.47) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL4052446 | 0.77 | MAPT (0.47) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL29644567 | 0.75 | MAPT (0.55) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4049010 | 0.72 | MEN1 (0.46) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL4055523 | 0.72 | BCHE (0.56) | MAPTALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL4054617 | 0.71 | GABRB1 (0.46) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL8074667 | 0.71 | SYK (0.42) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL31675860 | 0.71 | DRD2 (0.40) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL22501426 | 0.71 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026701-A1 | SIRTUIN INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |