Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 18/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058487 | 0.84 | MAPT (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4049526 | 0.76 | ADORA3 (0.38) | HDAC1HDAC6 | |
| SCHEMBL4163303 | 0.74 | HDAC1 (0.60) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL22501426 | 0.72 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL3959226 | 0.71 | ALDH1A1 (0.56) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL4417100 | 0.67 | HDAC1 (0.75) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL17183373 | 0.67 | HDAC1 (0.75) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL3955607 | 0.66 | SIRT1 (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL22501404 | 0.65 | HDAC3 (0.53) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL4152088 | 0.65 | HDAC1 (0.63) | HDAC3HDAC1HDAC2HDAC8HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026701-A1 | SIRTUIN INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |