Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059781 | 0.91 | L3MBTL1 (0.55) | MTNR1AMTNR1BL3MBTL1TDP1LMNA | |
| SCHEMBL468013 | 0.84 | MEN1 (0.58) | MTNR1AMTNR1BL3MBTL1TDP1HPGD | |
| SCHEMBL30027909 | 0.84 | MEN1 (0.58) | MTNR1AMTNR1BL3MBTL1TDP1HPGD | |
| SCHEMBL7798248 | 0.83 | TDP1 (0.53) | L3MBTL1TDP1LMNASMN1; SMN2MAPT | |
| SCHEMBL266821 | 0.82 | L3MBTL1 (0.64) | MTNR1AMTNR1BL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL29737506 | 0.82 | L3MBTL1 (0.64) | MTNR1AMTNR1BL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL27365553 | 0.81 | MTNR1A (0.59) | MTNR1AMTNR1BL3MBTL1TDP1LMNA | |
| SCHEMBL27728825 | 0.81 | L3MBTL1 (0.47) | L3MBTL1TDP1LMNASMN1; SMN2MAPT | |
| SCHEMBL10903457 | 0.81 | L3MBTL1 (0.52) | L3MBTL1TDP1LMNASMN1; SMN2MAPT | |
| SCHEMBL27283396 | 0.81 | L3MBTL1 (0.52) | L3MBTL1TDP1LMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109610-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2, 3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS | Nycomed GmbH (DE) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008095835-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2, 3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS | NYCOMED GMBH (DE) | 2008-08-14 | — | — | WO | disclosed |