Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 5/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008859 | 0.86 | MAOA (0.35) | PDE4B | |
| SCHEMBL4239976 | 0.83 | PDE4A (0.39) | DDB1CRBNPDE4BPIM1HRH4 | |
| SCHEMBL4053847 | 0.80 | CCR2 (0.33) | DDB1CRBNPDE4BPIM1 | |
| SCHEMBL4062007 | 0.75 | HRH4 (0.31) | HRH4 | |
| SCHEMBL4060696 | 0.75 | HRH4 (0.37) | HRH4 | |
| SCHEMBL4063486 | 0.73 | MYLK (0.33) | PDE4B | |
| SCHEMBL4059651 | 0.72 | KDR (0.35) | PDE4BPIM1 | |
| SCHEMBL12316272 | 0.72 | MAOA (0.35) | PDE4B | |
| SCHEMBL4235894 | 0.72 | HRH4 (0.35) | HRH4 | |
| SCHEMBL4541501 | 0.69 | PIM1 (0.31) | PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |